Understanding the dynamic relation between wastewater SARS-CoV-2 signal and clinical metrics throughout the pandemicArticle Published on 2022-12-202022-11-16 Journal: The Science of the total environment [Category] COVID19(2023년), SARS, 변종, [키워드] Alpha variant clinical testing Community complementary COVID-19 COVID-19 disease COVID-19 incidence deaths Delta VOC disease disease incidence Effectiveness expected Hospital admissions ICU admissions immunization incidence Infection Laboratory positive cases Metrics moderate omicron pandemic Population positive SARS-CoV-2 shown Spread Surveillance understanding vaccination vaccination rate Vaccine virulence VoC waned wastewater weakened widespread wildtype WWS. [DOI] 10.1016/j.scitotenv.2022.158458 PMC 바로가기
SARS-CoV-2 pseudovirus enters the host cells through spike protein-CD147 in an Arf6-dependent mannerSARS-CoV-2 슈도바이러스는 Arf6 의존적 방식으로 스파이크 단백질-CD147을 통해 숙주 세포에 들어갑니다.Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 approach Arf6 blockade CD147 cells clathrin Clathrin-mediated endocytosis clinically coronavirus endocytic endocytic mechanism endocytosis evaluate feasible function host cell host cells Huh-7 cell Huh-7 cells independent independent of indicated infected Vero E6 cells Infection inhibited inhibitor knockdown Localization macropinocytosis pathway Prevent pseudovirus pseudovirus infection public health RAB5A SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 pseudovirus SARS-CoV-2 pseudovirus infection severe acute respiratory syndrome Coronavirus Spike protein spike protein. Spread the SARS-CoV-2 variant Vero E6 VERO E6 cells viral infection weakened [DOI] 10.1080/22221751.2022.2059403 PMC 바로가기 [Article Type] Article
Impact of the COVID-19 pandemic on return and risk transmission between oil and precious metals: Evidence from DCC-GARCH modelResearch article Published on 2022-12-012022-10-05 Journal: Resources Policy [Category] 진단, [키워드] addition changed condition contribute correlation COVID-19 pandemic DCC-GARCH debates empirical finding Evidence Impact Oil pandemic positive Precious metals risk seeking The COVID-19 Transmission turn weakened [DOI] 10.1016/j.resourpol.2022.102939 [Article Type] Research article
Naturally occurring spike mutations influence the infectivity and immunogenicity of SARS-CoV-2Article Published on 2022-11-012022-11-15 Journal: Cellular and Molecular Immunology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] A570D A701V addition Affect affected antibodies antigenicity B.1.1.529 B.1.1.7 B.1.1.7 lineage B.1.351 B.1.617.2 BALB/c mice binding circulating cross-neutralization activity D1118H decrease Del Delta determine DNA vaccine Effects Efficiency elicited humoral immune response immune evasion immunized immunogen in vitro investigated K417N L18F Lineage Mutation NAbs Naturally neutralization Neutralizing Neutralizing antibodies neutralizing antibody NTD omicron opposite overcome P681H Pseudotyped viruses reduced S982A SARS-CoV-2 SARS-CoV-2 variant sera significantly increased single mutation single mutations spike mutation T cell T cell responses T-cell Response T716I tested the RBD Transmissibility unlikely Vaccine vaccine immunogenicity vaccine immunogenicity. variants of concern viral entry viral infectivity VoC VOCs was determined weakened [DOI] 10.1038/s41423-022-00924-8 PMC 바로가기
Individuals with obesity who survive SARS-CoV-2 infection have preserved antigen-specific T cell frequenciesArticle Published on 2022-10-012022-11-15 Journal: Obesity (Silver Spring, Md.) [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] Admission CD4 CD8 Cohort comparable COVID-19 cytokine response flow cytometry Frequency generate hepatitis B Hospitalization IFNγ IgG antibody titer immune dysregulation immune memory Immunity individual individuals Influenza intensive care investigated membrane Mortality Neutralizing obesity Patient peptide pool preserved reduced reported response risk factor robust SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike severe disease T cell T cell response T cell subset T cells TNFα vaccination weakened [DOI] 10.1002/oby.23526 PMC 바로가기
Rational design of AAVrh10-vectored ACE2 functional domain to broadly block the cell entry of SARS-CoV-2 variantsSARS-CoV-2 변이체의 세포 진입을 광범위하게 차단하기 위한 AAVrh10 벡터화 ACE2 기능 도메인의 합리적인 설계Article Published on 2022-09-012022-09-11 Journal: Antiviral Research [Category] Coronavirus, COVID19(2023년), SARS, 변종, [키워드] ACE2 ACE2 ortholog ACE2 orthologs adeno-associated virus Adeno-associated virus (AAV) vector amino acids angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 breadth Candidates cell entry comprehensive analysis COVID-19 COVID-19 vaccine domain Effectiveness Ex vivo exhibited fragment of functional higher affinity human ACE2 in silico in vitro Infection Interaction neutralizing antibody Protein RBD Receptor binding domain sACE2 sACE2. SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 variant SARS-CoV-2 variants serotype the RBD therapeutic strategy therapy These data tissue tropism variant variants virus was performed weakened [DOI] 10.1016/j.antiviral.2022.105383 PMC 바로가기 [Article Type] Article
A bibliometric analysis of the 100 most cited articles describing SARS-CoV-2 variantsArticle Published on 2022-08-262022-11-16 Journal: Frontiers in Public Health [Category] SARS, 변종, [키워드] acute respiratory syndrome addition adjusted Analysis analyzed Antibody neutralization antibody resistance article articles authors B.1.1.7 B.1.351 bibliometric analysis clinical trial coronavirus country COVID-19 D614G mutation database described dominant variant Efficacy England Epidemiology Evolution genomic information Genomics global public health identify immune Infection information journal majority measure Medicine MeSH term Mutation Nature neutralization Neutralizing New number public health ranged Research response SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants Science South Africa Spike protein the S protein the SARS-CoV-2 the spike protein Travel United Kingdom United States Vaccine vaccine-induced antibody variant Variant. variants weakened [DOI] 10.3389/fpubh.2022.966847 PMC 바로가기
T-cell responses to SARS-CoV-2 Omicron spike epitopes with mutations after the third booster dose of an inactivated vaccine비활성화 백신의 세 번째 추가 접종 후 돌연변이가 있는 SARS-CoV-2 오미크론 스파이크 에피토프에 대한 T 세포 반응Article Published on 2022-08-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 administration Antibody Response Antibody responses booster dose booster vaccination conserved CoronaVac coronavirus dose elicited enhancement Epitopes escape estimate evaluated Impact Inactivated vaccine individual individuals Infection mononuclear cell mononuclear cells Mutation mutations omicron Omicron variant participant Participants PBMCs peptide peptides Peripheral blood Peripheral blood mononuclear cells Protective respiratory SARS-CoV-2 severe acute respiratory syndrome Coronavirus significantly spike epitope Spike protein Spike proteins stimulate T-cell T-cell activation T-cell Response T-cell responses the SARS-CoV-2 the spike protein Vaccine vaccine. Vaccines variant virus volunteers weakened were used [DOI] 10.1002/jmv.27814 PMC 바로가기 [Article Type] Article
An analysis of 45 large-scale wastewater sites in England to estimate SARS-CoV-2 community prevalence Research Published on 2022-07-252022-10-05 Journal: Nature Communications [Category] COVID19(2023년), SARS, 치료기술, 치료법, [키워드] Analysis Asymptomatic can be used clinical testing Community complement COVID-19 pandemic England estimate implication infection prevalence infections Interpretation pre-symptomatic Prevalence public health resulting SARS-CoV-2 SARS-CoV-2 RNA sensitivity Surveillance symptomatic Variability viral infections virus weakened [DOI] 10.1038/s41467-022-31753-y [Article Type] Research
Proteomic and Metabolomic Characterization of SARS-CoV-2-Infected Cynomolgus Macaque at Early Stage초기 단계에서 SARS-CoV-2에 감염된 Cynomolgus Macaque의 단백질체 및 대사체 특성 분석Article Published on 2022-07-122022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] analyzed characterization COVID-19 COVID-19 infection cynomolgus macaque cynomolgus macaques Cytokines demonstrated dysregulated early infection early stage Efficacy effort feature Features immune immune response innate immune response lung tissue lung tissues lymphopenia macaque mechanism metabolomic profiling metabolomics moderate Moderate COVID-19 neutrophilia Pathogenesis pathogenic mechanism patients platelet activation proteomic proteomics SARS-CoV-2 SARS-COV-2 infection sera severe COVID-19 severe COVID-19 patients Stage Symptom the early stage. Therapeutics tissues Vaccine weakened [DOI] 10.3389/fimmu.2022.954121 PMC 바로가기 [Article Type] Article